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Venclexta (venetoclax)

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Acute Myeloid Leukemia

Azacitidine and Venetoclax versus Induction Chemotherapy for Untreated Acute Myeloid Leukemia (AML)

PARADIGM is a Phase 2, randomized, open-label, multicenter study evaluating the efficacy and safety of azacitidine plus venetoclax versus induction chemotherapy (IC) in newly diagnosed IC-eligible patients with AML.

The publication has been summarized for educational purposes and is available here:

Fathi AT, Perl AE, Fell GG, et al. Azacitidine-Venetoclax or Induction Chemotherapy for Acute Myeloid Leukemia. N Engl J Med. 2026;395(9):845-858. doi:10.1056/​NEJMoa2602804

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