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You can find out more about your selected topic at Medically, a different Genentech Medical website which includes information about investigational compounds and uses. The information presented does not imply US FDA approval and should not be construed as a recommendation for use. Do you wish to proceed?
You can find out more about your selected topic at Medically, a different Genentech Medical website which includes information about investigational compounds and uses. The information presented does not imply US FDA approval and should not be construed as a recommendation for use. Do you wish to proceed?
You can find out more about your selected topic at Medically, a different Genentech Medical website which includes information about investigational compounds and uses. The information presented does not imply US FDA approval and should not be construed as a recommendation for use. Do you wish to proceed?
You can find out more about your selected topic at Medically, a different Genentech Medical website which includes information about investigational compounds and uses. The information presented does not imply US FDA approval and should not be construed as a recommendation for use. Do you wish to proceed?
You can find out more about your selected topic at Medically, a different Genentech Medical website which includes information about investigational compounds and uses. The information presented does not imply US FDA approval and should not be construed as a recommendation for use. Do you wish to proceed?
You can find out more about your selected topic at Medically, a different Genentech Medical website which includes information about investigational compounds and uses. The information presented does not imply US FDA approval and should not be construed as a recommendation for use. Do you wish to proceed?
You can find out more about your selected topic at Medically, a different Genentech Medical website which includes information about investigational compounds and uses. The information presented does not imply US FDA approval and should not be construed as a recommendation for use. Do you wish to proceed?
You can find out more about your selected topic at Medically, a different Genentech Medical website which includes information about investigational compounds and uses. The information presented does not imply US FDA approval and should not be construed as a recommendation for use. Do you wish to proceed?
You can find out more about your selected topic at Medically, a different Genentech Medical website which includes information about investigational compounds and uses. The information presented does not imply US FDA approval and should not be construed as a recommendation for use. Do you wish to proceed?
You can find out more about your selected topic at Medically, a different Genentech Medical website which includes information about investigational compounds and uses. The information presented does not imply US FDA approval and should not be construed as a recommendation for use. Do you wish to proceed?
You can find out more about your selected topic at Medically, a different Genentech Medical website which includes information about investigational compounds and uses. The information presented does not imply US FDA approval and should not be construed as a recommendation for use. Do you wish to proceed?
You can find out more about your selected topic at Medically, a different Genentech Medical website which includes information about investigational compounds and uses. The information presented does not imply US FDA approval and should not be construed as a recommendation for use. Do you wish to proceed?
You can find out more about your selected topic at Medically, a different Genentech Medical website which includes information about investigational compounds and uses. The information presented does not imply US FDA approval and should not be construed as a recommendation for use. Do you wish to proceed?
You can find out more about your selected topic at Medically, a different Genentech Medical website which includes information about investigational compounds and uses. The information presented does not imply US FDA approval and should not be construed as a recommendation for use. Do you wish to proceed?
You can find out more about your selected topic at Medically, a different Genentech Medical website which includes information about investigational compounds and uses. The information presented does not imply US FDA approval and should not be construed as a recommendation for use. Do you wish to proceed?
You can find out more about your selected topic at Medically, a different Genentech Medical website which includes information about investigational compounds and uses. The information presented does not imply US FDA approval and should not be construed as a recommendation for use. Do you wish to proceed?
Ab: antibody
AE: adverse event
ASTCT: American Society for Transplantation and Cellular Therapy
CR: complete response
CRS: cytokine release syndrome
CT: computed tomography
CTCAE: Common Terminology Criteria for Adverse Events
DoR: duration of response
ECOG PS: Eastern Cooperative Oncology Group performance status
FL: follicular lymphoma
ICANS: immune effector cell-associated neurotoxicity syndrome
IRF: independent review facility
IV: intravenous
IQR: interquartile range
NCI CTCAE: National Center Institute Common Terminology Criteria for Adverse Events
NHL: non-Hodgkin lymphoma
ORR: objective response rate
PET: positron emission tomography
PFS: progression-free survival
PR: partial response
R/R: relapsed/refractory
SAE: serious adverse event
SD: stable disease
USPI: United States Prescribing Information
UTI: urinary tract infection
ADC: Antibody–drug conjugate
AE: Adverse event
ALT: Alanine aminotransferase
ASCO: American Society of Clinical Oncology
BC: Breast cancer
BMI: Body mass index
C: Cycle
CAP: College of American Pathologists
CCOD: Clinical cutoff date
CDK4/6: Cyclin-dependent kinase 4 and 6
CDx: Companion diagnostic test
CI: Confidence interval
CKD-EPI: Chronic Kidney Disease Epidemiology Collaboration
CTCAE v4.03: Common Terminology Criteria for Adverse Events version 4.03
CTCAE v4: Common Terminology Criteria for Adverse Events version 4
CTCAE v5.0: Common Terminology Criteria for Adverse Events version 5.0
CTCAE: Common Terminology Criteria for Adverse Events
ctDNA: Circulating tumor DNA
D: Day
DOR: Duration of response
DPP-4: Dipeptidyl peptidase-4
ECOG PS: Eastern Cooperative Oncology Group performance status
eGFR: Estimated glomerular filtration rate
ER: Endocrine receptor
ESMO: European Society for Medical Oncology
ESO: European School of Oncology
ET: Endocrine therapy
FDA: Food and Drug Administration
Fulv: Fulvestrant
HbA1c: Hemoglobin A1c
HCP: Health care provider/professional
HER2: Human epidermal growth factor receptor 2
HR: Hazard ratio or hormone receptor, depending on context
i: Inhibitor
IM: Intramuscular
Inavo: Inavolisib
IV: Intravenous
mBC: Metastatic breast cancer
MedDRA: Medical Dictionary for Regulatory Activities
MTD: Maximum tolerated dose
mTOR: Mammalian target of rapamycin
mut: Mutated
NCI: National Cancer Institute
NGS: Next-generation sequencing
ORR: Overall response rate
OS: Overall survival
Palbo: Palbociclib
PARP: Poly (ADP-ribose) polymerase
Pbo: Placebo
PCR: Polymerase chain reaction
PD: Progressive disease
PFS: Progression-free survival
PgR: Progesterone receptor
PI3K: Phosphatidylinositol 3-kinase
PIK3CA: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
PK: Pharmacokinetics
PO: By mouth
PRO: Patient-reported outcome
Q#W: Every # weeks
Q4W: Every 4 weeks
QD: Daily
R: Randomized
RECIST v1.1: Response Evaluation Criteria In Solid Tumors version 1.1
SAE: Serious adverse event
SGLT2: Sodium-glucose co-transporter 2
SOC: Standard of care
T: Type
ULN: Upper limit of normal
USPI: United States Prescribing Information
CD3: Cluster of differentiation 3
TCR: T-cell receptor
CD4: Cluster of differentiation 4
CD8: Cluster of differentiation 8
CD226: Cluster of differentiation 226
Ig: Immunoglobulin
ITIM: Immunoreceptor tyrosine-based inhibitory motif
MHC: Major histocompatibility complex
NK: Natural killer
PD-1: Programmed cell death protein 1
PD-L1: Programmed death-ligand 1
PVR: Poliovirus receptor
TIGIT: T-cell immunoreceptor with Ig and ITIM domains
ASTCT: American Society for Transplantation and Cellular Therapy
CD20: Cluster of differentiation 20
CR: Complete response
CRS: Cytokine release syndrome
CT: Computed tomography
CTCAE: Common Terminology Criteria for Adverse Events
DLBCL: Diffuse large B-cell lymphoma
DoCR: Duration of complete response
DoR: Duration of response
ECOG PS: Eastern Cooperative Oncology Group performance status
FL: Follicular lymphoma
HGBCL: High-grade B-cell lymphoma
ICANS: Immune effector cell-associated neurotoxicity syndrome
IRC: Independent Review Committee
NOS: Not otherwise specified
ORR: Objective response rate
PET: Positron emission tomography
PMBCL: Primary mediastinal B-cell lymphoma
AE: Adverse event
Ang2: Angiopoietin-2
ASTCT: American Society for Transplantation and Cellular Therapy
ATG: Anti-thymocyte globulin
CAR: Chimeric antigen receptor
CARTOX: CAR T-cell Therapy-Associated Toxicity
CD3: Cluster of differentiation 3
CPAP: Continuous positive airway pressure
CRP: C-reactive protein
CRS: Cytokine release syndrome
CTCAE: Common Terminology Criteria for Adverse Events
DIC: Disseminated intravascular coagulation
HLH: Hemophagocytic lymphohistiocytosis
ICANS: Immune effector cell–associated neurotoxicity syndrome
ICU: Intensive care unit
IFN-γ: Interferon-gamma
IL: Interleukin
INR: International normalized ratio
IRR: Infusion-related reaction
MAS: Macrophage activation syndrome
MSKCC: Memorial Sloan Kettering Cancer Center
NO: Nitric oxide
PTT: Partial thromboplastin time
TNF-α: Tumor necrosis factor alpha
VWF: von Wilebrand factor
AAAAI: American Academy of Allergy Asthma & Immunology
DMT: Disease-modifying therapy
HCP: Health Care Provider
Ig: Immunoglobulin
LLN: Lower limit of normal
MS: Multiple Sclerosis
NK: Natural killer
ACTRIMS: Americas Committee for Treatment and Research in Multiple Sclerosis
CMSC: Consortium of Multiple Sclerosis Centers
ECTRIMS: European Committee for Treatment and Research in Multiple Sclerosis
FAERS: FDA Adverse Event Reporting System
FDA: US Food and Drug Administration
Ig: Immunoglobulin
LMP: last menstrual cycle
MCA: major congenital anomalies
MS: Multiple sclerosis
OCR: OCREVUS (ocrelizumab)
PML: progressive multifocal leukoencephalopathy
PPMS: Primary progressive multiple sclerosis
RMS: Relapsing multiple sclerosis
CD19: Cluster of differentiation 19
CD20: Cluster of differentiation 20
CDC: Centers for Disease Control and Prevention
COVID-19: Coronavirus disease of 2019
DMT: Disease-modifying therapy
ECTRIMS: European Committee for Treatment and Research in Multiple Sclerosis
EMA: European Medicines Association
FDA: Food and Drug Administration
IgG1: Immunoglobulin G1
LMP: Last menstrual period
mAb: Monoclonal antibody
MCA: Major congenital anomalies
MS: Multiple sclerosis
OCR: OCREVUS (ocrelizumab)
RID: Relative infant dose
UCSF: University of California San Francisco
URTI: Upper respiratory tract infection
UTI: Urinary tract infection
ADA: antidrug antibody
AE: adverse event
AUC: area under the serum concentration–time curve
CCOD: clinical cut-off date
CI: confidence interval
Cmax: maximum serum concentration
CTCAE: Common Terminology Criteria for Adverse Events
EDSS: Expanded Disability Status Scale
Gd+: gadolinium-enhancing
GMR: geometric mean ratio
h: hour
IR: injection reaction
IV: intravenous
LIR: local injection reaction
LLOQ: lower limit of quantification
MedDRA: Medical Dictionary for Regulatory Activities
min: minutes
MRI: magnetic resonance imaging
MS: multiple sclerosis
N/A: not applicable
N/E: new/enlarging
OCR: ocrelizumab
PD: pharmacodynamic
PDR: protocol-defined relapse
PK: pharmacokinetics
PPMS: primary progressive multiple sclerosis
PRO: patient-reported outcome
rHuPH20: recombinant human hyaluronidase PH20
RMS: relapsing multiple sclerosis
RoA: route of administration
SC: subcutaneous
SIR: systemic injection reaction
Tmax: time to maximum concentration
USPI: United States Prescribing Information
W: week
ABC: activated B-cell–like subtype
BICR: blinded independent central review
CI: confidence interval
CNS: central nervous system
CR: complete response
DLBCL: diffuse large B-cell lymphoma
ECOG PS: Eastern Cooperative Oncology Group performance status
EFSefficacy: event-free survival for efficacy causes (time from randomization to the earliest occurrence of disease progression/relapse, death due to any cause, initiation of any non-protocol specified anti-lymphoma treatment, or biopsy-confirmed residual disease after treatment completion)
EOT: end of treatment
GCB: germinal-center B-cell–like subtype
HGBL: high-grade B-cell lymphoma
HHV8: human herpesvirus 8
HR: hazard ratio
INV: investigator
IPI: International Prognostic Index
ITT: intention-to-treat
LYSA: Lymphoma Study Association
NE: not evaluable
NOS: not otherwise specified
OS: overall survival
PET-CT: positron emission tomography and computed tomography
PFS: progression-free survival
Pola-R-CHP: polatuzumab plus rituximab, cyclophosphamide, doxorubicin, prednisone
R: randomization
R-CHOP: rituximab plus cyclophosphamide, doxorubicin, vincristine, prednisone
R-CHP: rituximab plus cyclophosphamide, doxorubicin, prednisone
USPI: United States Prescribing Information
ARR: Annualized Relapse Rate
ART: Assisted Reproductive Technology
CI: Confidence Interval
DMT: Disease-modifying therapy
EDSS: Expanded Disability Status Scale
MS: Multiple Sclerosis
T: Trimester
OR: Odds ratio
OB/Gyn: Obstetrics and Gynecology
DBPCFC: Double-blind, placebo-controlled food challenge
FDA: Food and Drug Administration
ICH: International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use
IgE: Immunoglobulin E
NIH: National Institutes of Health
OIT: Oral immunotherapy
OLE: Open-label extension
R: Randomized
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