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Pipeline & Clinical Trials

Explore the investigational molecules and recruiting clinical trials in our pipeline.

The clinical trials and molecule information included represent only a subset of the Roche/Genentech pipeline, specifically highlighting a selection of investigational molecules involved in actively recruiting Phase 3 trials. For a comprehensive overview of our full development portfolio or all actively recruiting Phase 3 trials, please visit genentech-clinicaltrials.com.

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Recruiting Trials

Explore select clinical trials that are actively recruiting participants. To view all clinical trials related to a molecule, go to the section below.

Phase III: Giredestrant in BC (pionERA Breast Cancer (BC))

A Phase III Randomized, Open-Label Study Evaluating Efficacy and Safety of Giredestrant Compared With Fulvestrant, Both Combined With a CDK4/6 Inhibitor, in Patients With Estrogen Receptor-Positive, HER2-Negative Advanced Breast Cancer With Resistance to Prior Adjuvant Endocrine Therapy

Phase III: Inavolisib in Breast Cancer (INAVO122)

A Phase III, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy and Safety of Inavolisib in Combination With Phesgo Versus Placebo in Combination With Phesgo As Maintenance Therapy After First Line Induction Therapy in Participants With PIK3CA-Mutated HER2-Positive Locally Advanced or Metastatic Breast Cancer

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Molecules

Explore our investigational molecules by phase. View individual molecules to explore all clinical trials related to that molecule.

Molecule Disease State Modality
Glofitamab Large B-cell lymphoma (LBCL), Mantle cell lymphoma (MCL) T cell-engaging bispecific antibody View Molecule

View Clinical Trials

Divarasib Non-small cell lung cancer (NSCLC) KRAS G12C inhibitor View Molecule

View Clinical Trials

Giredestrant Breast cancer Selective estrogen receptor degrader (SERD) View Molecule

View Clinical Trials

Inavolisib Breast cancer Phosphoinositide 3-kinase (PI3K) inhibitor View Molecule

View Clinical Trials

These compounds and their uses are investigational and have not been approved by the U.S. Food and Drug Administration. This information is presented only for purposes of providing a general overview of clinical trials and should not be construed as a recommendation for use of any product for unapproved uses.

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Call the Trial Information Support Team: 1-888-662-6728 Hours: Monday-Friday, 5am-5pm PT